Andrographis paniculata (Chuān Xīn Lián) for symptomatic relief of acute respiratory tract infections
Uit: PLOS ONE 12(8): e0181780 August 4, 2017, Xiao-Yang Hu et al.
Durk Meijer, MSc, physician | Antimicrobial resistance (AMR) is a substantial threat to public health. Controlling antibiotic resistance is of the utmost importance to ensure that antibiotics in the future also retain their efficacy in cases where their use is clinically necessary. Safe and effective alternatives are required to reduce unnecessary antibiotic prescribing. Andrographis paniculate (A. paniculata, Chuān Xīn Lia Ân) has traditionally been used in Indian and Chinese herbal medicine for cough, cold and influenza, suggesting a role in respiratory tract infections (RTIs). This systematic review aimed to evaluate the clinical effectiveness and safety of A. paniculata for symptoms of acute RTIs (ARTIs).
In this review, using the Cochrane method, English and Chinese databases were searched for randomized controlled trials investigating the oral administration of Andrographis paniculata, with thirty-three RCTs (7175 patients) were included.
Findings suggest limited but consistent evidence that A. paniculata improved cough and sore throat when compared with placebo. A. paniculata (alone or plus usual care) has a statistically significant effect in improving overall symptoms of ARTIs when compared to placebo, usual care, and other herbal therapies. Evidence also showed that A. paniculata shortened the duration of the symptoms.
Findings of this review showed A. paniculata pillules are superior to tablets in relieving overall symptoms, suggesting a place for pillule preparations.
Although no serious AE was observed and minor AE’s were mainly gastrointestinal in the included trials, caution is warranted in interpreting safety before comprehensive safety data is available.
The limitations that were encountered at are mentioned at the end of the research article.
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